I've only ever had 3 punctures (all occurred within 48hrs of each other) I think in this situation, you need to make sure the tyre goes back on in exactly the same place/direction - I did this using a couple of
biro marks and arrows - this allows you to find out whether punctures are due to particular part of the tyre. I only thought about this after the 2nd puncture and hey presto, 3rd ...