Opioid receptor - forum posts

Lamictal (Lamotrigine) action on mu opioid receptor -- LiveWire Teen Forums

Started 1 month, 4 weeks ago (2009-10-21 16:15:00) by ( Rickenbacker )

Here is an advanced pharmacology question for all you drug nerds. I take Lamictal (300mg) and it has proposed anti-depressant effects, possibly due to its unique ability to bind to the mu-opioid receptors as a mu-opioid agonist. I am considering moving to 400mg, but would like to know the comparison of 400mg Lamictal to a known opioid in activation of the mu-opioid site. I know this is a ...

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Forum: Teen Alcohol & Substance Abuse

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human study linking mu-opioid receptor gene with social sensitivity

Started 2 months ago (2009-10-20 11:35:00) by colors

Genetic Link Between Physical Pain And Social Rejection Found ScienceDaily (Aug. 21, 2009) UCLA psychologists have determined for the first time that a gene linked with physical pain sensitivity is associated with social pain sensitivity as well. Their study indicates that variation in the mu-opioid receptor gene (OPRM1), often associated with physical pain, is related to how ...

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Forum: Drugs in the Media

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RE: human study linking mu-opioid receptor gene with social sensitivity

Started 1 month, 3 weeks ago (2009-10-24 22:57:00) by qwe

Quote: When I discovered opiates they made the social anxiety/ phobia evaporate. And I had energy- I was outgoing, lucid, and sometimes witty. My luck with women skyrocketed that year and I eventually met my now wife i believe this is probly the main reason addiction takes hold in the suburbs. same story here. lucid definitely, as my ...

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Forum: Drugs in the Media

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RE: Okay, I gave my question a little more thought and the answer seems to be that my long-term use...

Started 2 months, 3 weeks ago (2009-09-24 00:00:00) by shibireru

Okay, I gave my question a little more thought and the answer seems to be that my long-term use of phenethylamine has provoked an upregulation of the transcription of the kappa opioid receptor-encoding gene or of the prodynorphin gene in my nucleus accumbens. Additionally, mu-opioid receptor agonists provoke a release of cortisol which in turn has the effect of releasing dynorphin, the principal...

Source: Bluelight

Forum: Advanced Drug Discussion

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RE: You can IV Suboxone and/or Subutex. The naloxone has nothing to do with it - it is essentially inert...

Started 2 months, 3 weeks ago (2009-09-24 00:00:00) by Captain.Heroin

You can IV Suboxone and/or Subutex. The naloxone has nothing to do with it - it is essentially inert due to the fact that buprenorphine out-competes naloxone for the mu-opioid receptor. The idea that you can't IV Suboxone is nothing more than a lie. There are countries with epidemics of people who shoot Suboxone - many people do it.

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Forum: Other Drugs

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RE: What's up with this opioid receptor talk for stimulants? I want absolutely zero opioid effects from stimulants. The idea...

Started 2 months, 3 weeks ago (2009-09-24 00:00:00) by bluedolphin

What's up with this opioid receptor talk for stimulants? I want absolutely zero opioid effects from stimulants. The idea stim for me would be MDPV with some GABA mixed in. Either that or for productivity and physical transparency propyl-amphetamine can't be beat.

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Forum: Advanced Drug Discussion

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RE: Action of Norspan: Buprenorphine stimulates the mu-opioid receptor which exerts primary analgesic effects. It also blocks the activity of...

Started 2 months, 3 weeks ago (2009-09-24 00:00:00) by nabollocks

Action of Norspan: Buprenorphine stimulates the mu-opioid receptor which exerts primary analgesic effects. It also blocks the activity of kappa-opioid receptor. The opioid agonist activities of buprenorphine are dose related. This means that above a certain dose there is no further analgesic effect. Each Norspan Transdermal Patch delivers buprenorphine over a period of seven days. ...

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Forum: Other Drugs

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RE: Quote: Originally Posted by animalman Another note is using two kinds of opiates at the same time: bad idea....

Started 2 months, 3 weeks ago (2009-09-24 00:00:00) by morphonorconic

Quote: Originally Posted by animalman Another note is using two kinds of opiates at the same time: bad idea. Eventhough they both are mu opioid receptor agonists, the small difference in chemical structure only allows one of them to activate the receptor, they cant both fit onto it, so you create a "competition" between the two and the ...

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Forum: Other Drugs

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RE: You shouldn't have to be piss tested to get Suboxone. Get treatment from a different doctor if that's the...

Started 2 months, 3 weeks ago (2009-09-23 00:00:00) by Captain.Heroin

You shouldn't have to be piss tested to get Suboxone. Get treatment from a different doctor if that's the problem. Too much buprenorphine won't cause "withdrawal" what it will do is it'll antagonize itself at the mu-opioid receptor...it'll cause agitation, etc. It's rather unpleasant - a lot better to use less.

Source: Bluelight

Forum: Other Drugs

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