While my acne was never very bad, I have a tendency to pick terribly at the pimples I do get, making them so much worse, that I finally went on Accutane a few years ago. I didn't experience depression and I haven't gotten any IBS and my acne cleared up. I did experience
extreme thirst (and, therefore, frequent urination), a migraine any time my dosage was changed, and a very rare side ...