Thread: Tamoxifen and CYP2D6 testing

( Hi Beverly, Really interesting and I hope we can stay in touch to see how your treatment unfolds. I lived in 'peg for 10 years \(thus the M part of my handle!\), so can relate a bit with where you are! , )

( Hello Covertanjou, I am seeing Dr. Ferrario and I asked him about the test and he did not know about it beeing done.  But he was open.  I have  not asked again as I am not there yet but will follow up later.  Knowing that I have the option to get it done on my own is good too \(thanks bcamnb for the info!\). Let me know what you find out.  I am trying to sort out surgery and...

( I went to Mayo in Feb/09.  \(just before I started chemo\)  We went to get a 2nd opinion and also for the cyp2d6 test.  \(Things happened before my diagnosis that we were not happy about.\)   We did not know at that time that you could do it how you did it.  I had my surgery, chemo and rads in Winnipeg \(where I live\).  We met with an oncologist at the Mayo and we did leave with some...

( Caroline, I am taking it at night and with food.  The nausea is better today, so I hope my body is getting used to it.  I will definitely look into getting the test to see if I metabolize the tamox. Yo, Good luck with your surgery.  You are at a great hospital and that makes a difference.  Mary  , )

My onc said that if you are having hot flashes, then you are probably metabolizing.  I started Zoladex at the same time as Tamoxifen, and did have hot flashes,  She said that you usually dont have hot flashes right away from Zoladex and my hot flashes are probably from the tamoxifen which would show i was a good metabolizer.  Anyway, I thought it was important enough to be tested.  So I shelled out $400,...

( Even worse than being an intermediate metabolizer is being a poor or non-metabolizer -- 7 to 11% of the population -- I found out I'm in that "special" group , with two "null" alleles for CYP2D6, so I'm REALLY glad my onc had me tested -- I was completely unaware of this issue before she mentioned she was ordering this test., )

I was told by my ONC that it's not an official test and not proved yet...some famous ONC in US never used it.

( hi all, i just found out about this test and phone my oncologist.  i was told that the credit valley hospital in mississauga, ontario is not going to have any of their patients take this test...not happy with this as i do not think they are being supportive if we are interested...i found out about it from a session at wellspring \(a caring organization for those living with cancer\) from an oncologist at a brampton hospital...he is...