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Thread: Tamoxifen (ER+, ER-, synergies etc)
Started 1 month, 3 weeks ago by Rich66
Tamoxifen: the drug that came in from the cold http://www.nature.com/bjc/journal/v1.../6605231a.h tml L Hughes-Davies1, C Caldas2,3 and GC Wishart*,1,3 1Cambridge Breast Unit, Addenbrooke’s Hospital, Hills Road, Cambridge, UK; 2Department of Oncology, University of Cambridge, and Functional Breast Cancer Genomics Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing ...
Site: HER2 Support Group Forums  HER2 Support Group Forums - site profile
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Total thread posts: 18 posts
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Rich66 replied 1 month, 3 weeks ago
Int J Oncol. 2007 Feb;30(2):509-20. Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer. Osipo C , Meeke K , Cheng D , Weichel A , Bertucci A , Liu H , Jordan VC . Department of Pathology, Oncology Institute, Cardinal Bernadin Cancer Center, Loyola University Medical Center, Maywood, IL, USA. Tamoxifen resistance is common for estrogen receptor alpha (ERalpha) ...
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Rich66 replied 1 month, 3 weeks ago
1: Clin Cancer Res. 2009 Jan 1;15(1):119-30. Links Preferential killing of breast tumor initiating cells by N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine/ tesmilifene. Deng T , Liu JC , Pritchard KI , Eisen A , Zacksenhaus E . Toronto General Research Institute-University Health Network, Ontario, Canada. PURPOSE: N,N-Diethyl-2-[4-(...
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Rich66 replied 1 month, 3 weeks ago
1: Mol Cancer Ther. 2008 Sep;7(9):3056-63. Links Methylseleninic acid synergizes with tamoxifen to induce caspase-mediated apoptosis in breast cancer cells. Li Z , Carrier L , Rowan BG . Department of Structural and Cellular Biology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA. Tamoxifen has efficacy as a breast ...
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Rich66 replied 1 month, 3 weeks ago
New - Read the press release on Tamoxitest Tamoxitest -- Cytochrome P-450 2D6 Genotyping Click here to download an information package Tamoxifen is a SERM (Selective Estrogen Receptor Modulators) used to treat treat breast cancer by preventing the binding of estrogen to breast cells. Tamoxifen is metabolized by the ...
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Rich66 replied 1 month, 3 weeks ago
Menin, a product of the MENI gene, binds to estrogen receptor to enhance its activity in breast cancer cells: possibility of a novel predictive factor for tamoxifen resistance Breast Cancer Research and Treatment, 11/04/09 Free Abstract Imachi H et al. – Menin can function as a transcriptional...
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Rich66 replied 1 month, 3 weeks ago
Cancer Res. 2008 Nov 1;68(21):8908-17. ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancer. Riggins RB , Lan JP , Zhu Y , Klimach U , Zwart A , Cavalli LR , Haddad BR , Chen L , Gong T , Xuan J , Ethier SP , Clarke R . Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, ...
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Rich66 replied 1 month, 2 weeks ago
Did this ever get investigated/confirmed? J Membr Biol. 2001 May 15;181(2):125-35. Inhibition of glial Na+ and K+ currents by tamoxifen. Smitherman KA , Sontheimer H . Department of Neurobiology and Cell Biology and Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Tamoxifen (tmx) is a non-steroidal triphenylethylene derivative that...
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schoolteacher replied 1 month, 2 weeks ago
Rich, I would also like to know if this is true. I hope it is true. Amelia
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Rich66 replied 1 month, 2 weeks ago
http://www.cytogen.com SOLTAMOX is a sugar-free, clear colorless liquid, with licorice and aniseed odor and taste. It is supplied in a 150mL bottle. Each 5mL dose contains 15.2 mg tamoxifen citrate, which is equivalent to 10 mg tamoxifen. The recommended daily dose is 20-40 mg. Dosages greater than 20 mg per day should be divided into morning and evening doses. A 20 mg dose of SOLTAMOX is ...
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DianneS replied 1 month, 1 week ago
I started Tamoxifen 10 days ago. I finished Herceptin in Sept. and my onc wanted me to wait a bit before starting the hormone therapy as I felt a bit nauseated on Herceptin. Now I hope I didn't wait too long to begin hormone therapy? Does anyone know the optimal time to start? I am weakly ER+ so my benefit, as I have said before, is about 4-6%. I have very few symptoms on the ...
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Top contributing authors

Name
Posts
Rich66
14
user's latest post:
Tamoxifen (ER+, ER-, synergies etc)
Published (2009-12-05 00:20:00)
Abstract 2007 ASCO In vivo and in vitro efficacy of capecitabine (X) + tamoxifen (TAM) in breast cancer (BC) K. Mori, Y. Yamaguchi, N. Sawada, K. Kondoh and S. Hayashi Chugai Pharmaceutical Co, Kamakura, Japan; Saitama Cancer Center, Ina-machi, Japan; School of Medicine, Tohoku University, Sendai, Japan 21092 Background: In vitro studies in BC cell lines suggested antagonism between TAM and 5-FU. Thymidine phosphorylase (TP) activates X to...
DianneS
3
user's latest post:
Tamoxifen (ER+, ER-, synergies etc)
Published (2009-11-16 00:27:00)
Nope, no difficulty in swallowing pills! Esp. small ones such as Tamoxifen. I did do a DNA test that said I am a normal metabolizer for Tamoxifen as well as many other drugs. This is a good thing...too bad I'm only weakly ER positive eh? Dianne
schoolteacher
1
user's latest post:
Tamoxifen (ER+, ER-, synergies etc)
Published (2009-11-09 13:40:00)
Rich, I would also like to know if this is true. I hope it is true. Amelia

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