Thread: Short-Term Spikes May Lead To Diabetes Complications

The A1c accounts for less than 25% of the variation in risks of diabetes complications. Short-term spikes (such as post meal spikes) may contribute to the development of diabetes complications. Here is the link: Transient high glucose causes persistent epigeneti...[J Exp Med. 2008] - PubMed Result

That is interesting in theory Richard but these are mice. I'd like to see the study results of actual People. That would not be hard to come by. And would this damage be reversable? I didn't notice a time span for the high numbers. Days, weeks, months? The theory is probably correct in Humans also. Everyone would have the damage then, even so slightly.

[quote=Richard157;4885]The A1c accounts for less than 25% of the variation in risks of diabetes complications. Short-term spikes (such as post meal spikes) may contribute to the development of diabetes complications. Here is the link: quote] I think this study is overstating their findings. Until the full mechanism by which hyperglycemia exerts its vascular damage is known, I dont think we can determine what causes the most significant issues.