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Vaccine. 2009 Nov 17. [Epub ahead of print] A phase I evaluation of inactivated influenza A/H5N1 vaccine administered by the intradermal or the intramuscular route. Patel SM, Atmar RL, Sahly HE, Cate TR, Keitel WA. - Baylor College of Medicine, Medicine - Infectious Diseases, BCM MS 280, One Baylor Plaza, Houston, TX 77030, United States. In a phase I clinical trial, one hundred healthy young adults were randomized to receive two doses 28...

Quote: Originally Posted by Harfang des Neiges I'll second St-Michael and Vibrant62 on that. I understand both positions, and admit it is an ethical catch 22: From a public health perspective (as well as a global social justice perspective), many more individuals can be treated using adjuvants. Its the age old debate: when do individual rights trump those of the greater good of a society? When does the government's need to immunize...

Quote: It seems to reflect a sort of psychological contagion of myth and suspicion. Sometimes some people transpose the possible into the probable. Listening to the news and watching the many "action" shows, a young child can get imprinted with the assumption that the world is full of people with the worst of intentions. How big of a leap is it for that child to become a fearful adult? .

You should have mention that DMS has previously (> 3 years ago) received research grant funding from GSK and Sanofi-Pasteur. It would be interesting to see if there is an explanation why few develop antibodies via seasonal flu vaccine...

It will be interesting to follow this graph from AFHSC of "Incidence Rate of P&I and ILI among Active Duty Service Members" (comparing SEASONAL vaccinated vs unvaccinated) http://www.afhsc.mil/Documents/Flu_R...009_Week46.pdf

The critical section in this article. . . The dramatic shift in public sentiment over the course of this H1N1 epidemic is both fascinat- ng and frustrating. It is clear that here is a distinct emotional epi- demiology and that it bears only faint connection to the actual disease epidemiology of the virus. We cannot combat H1N1 in- luenza merely by ensuring ade- quate supplies of vaccine and oseltamivir. Unless the medical profession confronts...

Quote: A na?ve or uncommitted Th cell can go in any one of several different directions, depending on which cytokines are present in the immediate micro-environment where the immune response is taking place, eg vaccination site and/or local lymph nodes. You can see the Th1 and Th2 cells, as per the older paradigm, but the important story is in the lower half of the diagram. Notice that the presence of TGF-beta favors the formation of...

Iranian J Publ Health, Vol. 38, No.2, 2009, pp.51-57 http://ijph.ir/pdfs/6-Dr_Hajabdolbaghi%20RTL!!.pdf Adverse Events of Trivalent Influenza Vaccine among Health Care Workers in Iran Abstract Background: To assess the frequency and type of adverse events after influenza vaccination in Iranian adults. Methods: Health care workers in 7 medical centers received the influenza vaccine from October 2006 to February 2007 and followed by phone...

Quote: Originally Posted by Vibrant62 IMHO - there are strong arguments for use of adjuvant vaccines as Marcovth has indicated - but there are strong reasons for cautions in some groups too. I still fail to see WHY it should not be possible to employ both strategies:- use adjuvant vaccine for the bulk of the healthy population and those over 65 in whom there is a reasonable experience of adjuvant use (who are the vast majority) to make...

Here are the two major advantages of adjuvant vaccinations. * You need less antigen. - For every U.S. adjuvant-free vaccination, Canada/Europe can vaccinate four adults or eight children (half dose) with adjuvant containing shots. Theoretically, this means you can protect your population four times faster. I assume you can expect less deaths if you can protect your population four times faster. Note: the production problems with GSK in Canada...