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Selection bias explains seasonal vaccine's protection -- Janjua et al. 339: b4972 (BMJ, extracts, edited) Published 24 November 2009, doi:10.1136/bmj.b4972 Cite this as: BMJ 2009;339:b4972 Letters Seasonal vaccine and H1N1 - Selection bias explains seasonal vaccine’s protection The first 150 words of the full text of this article appear below. Vaccine efficacy is estimated to be around 80% for trivalent inactivated flu vaccine during...

Journal of Psychosomatic Research Volume 67, Issue 1, Pages 37-43 (July 2009) Cardiovascular activity and the antibody response to vaccination Anna C. Phillips, Douglas Carroll, Victoria E. Burns, Mark Drayson Received 5 August 2008; received in revised form 1 December 2008; accepted 2 December 2008. published online 05 March 2009. Abstract Objective To examine the relationship between cardiovascular activity in response to acute...

New production techniques are mostly years away from being implemented By Rob Stein Washington Post Staff Writer Tuesday, November 24, 2009 After a lethal bird flu virus emerged in Asia, U.S. officials launched an intense effort to build new defenses against a pandemic, including replacing an antiquated vaccine system , which depends on millions of chicken eggs. But six years later, as Americans from Washington to California line up to get...

Quote: A na?ve or uncommitted Th cell can go in any one of several different directions, depending on which cytokines are present in the immediate micro-environment where the immune response is taking place, eg vaccination site and/or local lymph nodes. You can see the Th1 and Th2 cells, as per the older paradigm, but the important story is in the lower half of the diagram. Notice that the presence of TGF-beta favors the formation of...

Iranian J Publ Health, Vol. 38, No.2, 2009, pp.51-57 http://ijph.ir/pdfs/6-Dr_Hajabdolbaghi%20RTL!!.pdf Adverse Events of Trivalent Influenza Vaccine among Health Care Workers in Iran Abstract Background: To assess the frequency and type of adverse events after influenza vaccination in Iranian adults. Methods: Health care workers in 7 medical centers received the influenza vaccine from October 2006 to February 2007 and followed by phone...

#5: "Its the age old debate: when do individual rights trump those of the greater good of a society? When does the government's need to immunize the greater number of individuals trump the rights of the individual? Should one first world citizen have access to a safer vaccine at the expense of several third world citizens getting no vaccine ." The societies have enaugh time from 2005 to arrange, enlarge and build, more vaccine...

IMHO - there are strong arguments for use of adjuvant vaccines as Marcovth has indicated - but there are strong reasons for cautions in some groups too. I still fail to see WHY it should not be possible to employ both strategies:- use adjuvant vaccine for the bulk of the healthy population and those over 65 in whom there is a reasonable experience of adjuvant use (who are the vast majority) to make vaccinations go further and use non adjuvant...

The critical section in this article. . . The dramatic shift in public sentiment over the course of this H1N1 epidemic is both fascinat- ng and frustrating. It is clear that here is a distinct emotional epi- demiology and that it bears only faint connection to the actual disease epidemiology of the virus. We cannot combat H1N1 in- luenza merely by ensuring ade- quate supplies of vaccine and oseltamivir. Unless the medical profession confronts...

It will be interesting to follow this graph from AFHSC of "Incidence Rate of P&I and ILI among Active Duty Service Members" (comparing SEASONAL vaccinated vs unvaccinated) http://www.afhsc.mil/Documents/Flu_R...009_Week46.pdf

Here are the two major advantages of adjuvant vaccinations. * You need less antigen. - For every U.S. adjuvant-free vaccination, Canada/Europe can vaccinate four adults or eight children (half dose) with adjuvant containing shots. Theoretically, this means you can protect your population four times faster. I assume you can expect less deaths if you can protect your population four times faster. Note: the production problems with GSK in Canada...